A Systematic Review on Exploration of Extracts and Phytochemicals for Peptic Ulcer from 2018 to 2024.

This systematic review examined research published between 2018 and 2024 on plant extracts and natural compounds for treating peptic ulcers, a condition affecting millions worldwide. The researchers searched multiple scientific databases including PubMed, Scopus, and ScienceDirect to identify studies on botanical medicines with anti-ulcer properties. They found that traditional healers and Ayurvedic physicians have long used various medicinal plants to treat ulcers, and modern research supports many of these practices. The review identified numerous plants with anti-ulcer potential, including turmeric, orange, moringa, and myrrh, along with specific bioactive compounds like gingerol, chrysin, and limonene. These natural remedies appear to work through multiple mechanisms: protecting the stomach lining (mucosa), reducing inflammation, blocking inflammatory signals, and decreasing harmful bacterial loads. The findings suggest that herbal medicines containing active metabolites can improve quality of life for ulcer patients. This research is particularly important because traditional ulcer medications are becoming less effective due to increasing drug resistance, while newer synthetic drugs are expensive and often cause more side effects than natural alternatives. The review supports the potential for developing safer, more affordable ulcer treatments based on traditional plant medicines.