A Systematic Review on Exploration of Extracts and Phytochemicals for Peptic Ulcer from 2018 to 2024.

This systematic review examined research published between 2018 and 2024 on plant extracts and natural compounds for treating peptic ulcers, a condition affecting millions worldwide. The researchers searched multiple scientific databases including PubMed, Scopus, and ScienceDirect to identify studies on botanical medicines with anti-ulcer properties. They found that traditional healers and Ayurvedic physicians have long used various medicinal plants to treat ulcers, and modern research supports many of these applications. The review identified numerous promising plants including turmeric (Curcuma longa), orange (Citrus sinensis), moringa (Moringa oleifera), and several others, along with specific bioactive compounds like gingerol, crocin, and limonene that show anti-ulcer effects. The researchers found that these natural remedies work through multiple mechanisms: protecting the stomach lining (mucosa), reducing inflammation, blocking inflammatory signaling molecules, and decreasing bacterial load in the digestive system. This research matters because peptic ulcer disease is increasingly resistant to conventional medications, which are also expensive and often cause significant side effects. Natural plant-based treatments offer potentially safer, more affordable alternatives that could improve quality of life for ulcer patients while providing multiple therapeutic benefits through their complex mixture of active compounds.